Multivariate Cox regression analysis further demonstrated that low HOXA5 expression was an independent predictive indicator for overall survival (hazard ratio [HR] 1.758, 95% confidence interval [CI], 1.295-2.386; p < 0.001) and recurrence-free survival (hazard ratio [HR] 1.625, 95% confidence interval [CI], 1.239-2.132; p < 0.001) in HCC (Table S4). Here, HOXA5 is linked to hepatocellular carcinoma.