The hypervascular nature underlines the importance of angiogenesis in most HCC tumors 36.Based on our research, we may be the first to discover that both the in vitro and in vivo down-regulation of HOXA5 promoted angiogenesis, and HOXA5 was regulated by the Sp1/miR-130b-3p axis and inhibited angiogenesis in HCC via the PI3K/AKT/mTOR signaling pathway. The gene discussed is HOXA5; the disease is hepatocellular carcinoma.