The exposure of CXCR4+ DLBCL cells to T22-PE24-H6, during the 15 h to 48 h exposure period, caused a decrease of the pro-caspase-3 and PARP expression together with the increase of both cleaved caspase-3 and cleaved PARP that occurred at the final stage of cell death (Figure 3E-F). This evidence concerns the gene CXCR4 and diffuse large B-cell lymphoma.