CXCR4 and diffuse large B-cell lymphoma: Indeed, T22-PE24-H6 could improve treatment outcomes in CXCR4+ diffuse large B-cell lymphoma (DLBCL) patients, because of their association with poor progression-free as well as overall survival in R-CHOP treated patients; and also because CXCR4+ DLBCL cells are responsible for relapse and resistance to R-CHOP 22-24.