In addition to associations with obesity risk genes (SNP rs13078807 located in the second intron of CADM2) novel associations of CADM2 genetic variants with systolic blood pressure (SBP), CRP levels (Morris et al., 2019), as well as with diverse psychological traits (neuroticism, mood instability, and risk-taking) have been detected. Here, CADM2 is linked to obesity due to melanocortin 4 receptor deficiency.