Quantitative real-time PCR in post-mortem brain slices of MDD patients showed a significant decrease in mRNA levels of CYP17A1 (Qi et al., 2018) and genetic variants of the rs743572 polymorphism of CYP17A1 were correlated with the intensity of depressive symptoms in post-menopausal women (Loja-Chango et al., 2016), altogether suggesting a role of CYP17A1 in mood disorders. Here, CYP17A1 is linked to mood disorder.