Therefore, these 15 genes (LPL, COL4A2, PLG, CDKN2B, COL4A1, FES, FLT1, FN1, IL6R, LPA, PCSK9, PSRC1, SMAD3, SWAP70, and VAMP8) were considered as the most promising causal genes for CAD. This evidence concerns the gene COL4A1 and coronary artery disorder.