Therefore, these 15 genes (LPL, COL4A2, PLG, CDKN2B, COL4A1, FES, FLT1, FN1, IL6R, LPA, PCSK9, PSRC1, SMAD3, SWAP70, and VAMP8) were considered as the most promising causal genes for CAD. The gene discussed is IL6R; the disease is coronary artery disorder.