MAEL and gastric cancer: He et al. (2016) identified Kelch-like protein 24 (KLHL24) as a maintainer of skin integrity by balancing degradation and intermediate filament stability. MAELSTROM protein (MAEL) is a novel diagnostic biomarker for gastric cancer. A previous study revealed that the function of MAEL is closely linked to epithelial–mesenchymal transition (EMT) and stem cell properties (Zhang et al., 2017). Lck Interacting Transmembrane Adaptor 1 (LIME1) is a transmembrane adaptor involved in the activation of BCR (B-cell antigen receptor)-mediated signaling via interaction with Lck and Lyn (Hořejšì, 2004).