They are inflammatory bowel disease (IBD) (hsa05321), Th17 cell differentiation (hsa04659), cytokine–cytokine receptor interaction (hsa04060), Th1 and Th2 cell differentiation (hsa04658), JAK-STAT signaling pathway (hsa04630) and chagas disease (American trypanosomiasis) (hsa05142). Here, IL18R1 is linked to American trypanosomiasis.