On the one hand, a majority of genes in MHC region are related to immune response which may bring false positives (Pividori et al., 2019); on the other hand, for asthma and allergy diseases, MHC region was reported as containing some of the strongest association signals such as HLA-DQB and HLA-B (Waage et al., 2018). The gene discussed is HLA-DQB1; the disease is asthma.