In addition to the effect on cancer cell proliferation and survival, the IL-17B/IL-17RB signaling pathway induces stemness and epithelial to mesenchymal transition (EMT) of MGC-803 gastric cancer cells through activation of the AKT/GSK-3β/β-catenin pathway and the up-regulation of Sox2, Oct4, and Nanog proteins. The gene discussed is IL17RB; the disease is cancer.