Moreover, the pro-angiogenesis effect of the other cargo of MSC-EVs had been investigated in vitro and in vivo MI models, including miR-210 (66), miR-21 (68), platelet-derived growth factor D (PDGF-D) (69), hypoxia-inducible factor 1-alpha (HIF1-α) (70), and extracellular matrix metalloproteinase inducer (EMMPRIN) (71) and angiopoietin (72). This evidence concerns the gene HIF1A and myocardial infarction.