CD4 and infection: Eight upregulated genes (5.7%) were common to infection of AMTBs with both clinical isolates of Mtb (Figure 1B, Supplementary Table 2) and were mainly associated with functional categories of ISGs (Figures 4E,F), including IFIT2, IFIT3, MX1, HELZ2, EPSTI1, CSRNP1, and CXCL9, which are induced by IFN-γ and participate in the recruitment of activated CD4 T cells and monocytes (56).