Thus, 22 genes (15.7%) were exclusively upregulated in response to infection with UT127 (Figure 1B, Supplementary Table 2), including receptors (AIM2, CD274, CD83, FCGR1A, and GPR132), enzymes (B4GALT5, GK, MTHFD2, PIM1, and WARS), cytokines (IL15, IL27, TNFAIP8, and TNFSF10), IFN-inducible genes (IFI44L and IFIH1), protein-trafficking (LAMP3, ANKRD22, RFTN1, and STX11), and transcription factors (ARID5B and STAT4). The gene discussed is MTHFD2; the disease is infection.