In response to infection with UT205, AMTBs induced the expression of five genes (3.6%) (Figure 1B, Supplementary Table 2) associated with positive regulation of interleukin-23 production (CSF2, IFNG), myeloid cell differentiation (CSF2, IFNG, ISG15, SERPINE2), response to type I IFN, and negative regulation of cytokine production (IFIT1, ISG15) (Figures 4C,D). The gene discussed is ISG15; the disease is infection.