BCR and diffuse large B-cell lymphoma: Interestingly, it has also been found that although many B cell lymphomas depend on intact tonic or antigen-driven BCR signaling, a subset of diffuse large B cell lymphomas (DLBCL), called OxPhos DLBCL, with gene expression signature enriched in oxidative phosphorylation genes, does not express functional BCR (63, 64), pointing toward separation of these signal pathways.