Interestingly, it has also been found that although many B cell lymphomas depend on intact tonic or antigen-driven BCR signaling, a subset of diffuse large B cell lymphomas (DLBCL), called OxPhos DLBCL, with gene expression signature enriched in oxidative phosphorylation genes, does not express functional BCR (63, 64), pointing toward separation of these signal pathways. The gene discussed is BCR; the disease is B-cell non-Hodgkin lymphoma.