SMAD3 and Hepatic fibrosis: Our study showed that myricetin suppressed the expression of TGFβ1, phospho-Smad2, phospho-Smad3, phosph-ERK1/2, Akt, phospho-Akt in schistosome-infected mice, revealing that myricetin may reduce liver fibrosis in schistosome-infected mice by inhibiting TGFβ1/Smad/ERK and PI3K/Akt signaling.