ZIKV infection stimulates the interferon system and thus the production of type I (IFN-α, β), type II (IFN-γ), and type III IFNs (IFN-λ1–4) followed by the induction of IFN stimulated genes such as small membrane-associated interferon-inducible transmembrane proteins (IFITMs) that interfere with specific steps of the viral life cycle (31, 88, 89). Here, IFNA1 is linked to Zika virus infectious disease.