A comprehensive genome-wide analysis of human mRNA expression in skin lesions of all forms of leprosy (TT, BT, BB, BL, LL, T1R, and T2R) was performed using microarrays, RT-PCR, and immunohistochemistry, and different forms of leprosy showed some unique differentially expressed genes, such as GPNMB, IL1B, MICAL2, and FOXQ1 in T1R and AKR1B10, FAM180B, FOXQ1, NNMT, NR1D1, PTX3, and TNFRSF25 in T2R (26). The gene discussed is TNFRSF25; the disease is leprosy.