C3 depletion with Cobra Venom Factor (CVF) prevented GN after passive transfer of anti-MPO IgG or anti-MPO splenocytes (17), though C3aR deficient mice are not protected from glomerular injury after passive transfer of anti-MPO IgG (43), and C3aR is not required for neutrophil priming (40). This evidence concerns the gene C3AR1 and ganglioneuroma.