MPO and ganglioneuroma: Transfer of splenocytes (including both T and B cells) from Mpo−/− mice hyperimmunized with either MPO (or BSA as a control protein) into immunodeficient Rag2−/− mice resulted in detectable serum anti-MPO antibodies within 3 days with dose-dependent necrotising and crescentic GN and renal impairment by day 13, as well as variable involvement of other organs.