MPO and ganglioneuroma: Transfer of anti-MPO IgG, from MPO-immunized Mpo−/− mice, into C57BL/6 mice and Rag2−/− mice (that lack T and B lymphocytes) caused focal necrotising and crescentic pauci-immune GN, demonstrating the pathogenicity of ANCA in vivo and its role in acute glomerular injury (15).