At 5 d after the infection, C5aR2 was only significantly upregulated in the liver of infected males compared to the saline group (p = 0.02), while C5aR1 expression in the liver was consistently upregulated in both sexes (p < 0.0001 in males and p = 0.002 in females; Figure 8B). This evidence concerns the gene C5AR2 and infection.