For example, the five single nucleotide polymorphisms in the human Cytokine-inducible Src homology 2 domain-containing protein (CISH) gene (three of which lie in the promoter region) that have been associated with increased risk to malaria (Khor et al., 2010) can now be experimentally validated for the contribution to malaria anemia using Cish knockout mice infected with P. berghei. The gene discussed is CISH; the disease is malaria.