NR3C2 and obesity due to melanocortin 4 receptor deficiency: Preclinical studies have demonstrated that activation of MR works on adipocyte function, resulting in significant changes in biochemical and morphological markers of adipose tissue differentiation (6, 7) positioning MR as a fundamental proadipogenic transcription factor modulating the effects of aldosterone and glucocorticoids on adipose tissue and its pathophysiological role in obesity and the metabolic syndrome (8, 9).