In our obesity model, mice fed with HFD not only showed an increase in circulating aldosterone but also a significant increase on the expression levels of the AT1R, AT2R, CYP11B2, and MR genes in adipose tissue than those in the ND group, an increase that was attenuated within mice in the presence of eplerenone. Here, CYP11B2 is linked to obesity due to melanocortin 4 receptor deficiency.