It has been proposed that in obesity, dendritic cell (DC) particularly recruit the CD11b+ subset (65), and promote Th17 and Th2 cell responses, increasing their production of proinflammatory cytokines, such as IL6, IL1b, and IL23 (66, 67), which is consistent with the observation in the HFD mice where IL6 expression was significantly increased when compared to the expression associated with the control and HFD-E treatments. Here, IL1B is linked to obesity due to melanocortin 4 receptor deficiency.