Considering the clinical outcome (n = 104 ACC), OS showed no relationship with CDK4 protein expression (p = 0.2013, data not shown), while PFS was slightly longer in patients with high CDK4 nuclear expression compared to patients with low expression (median=24 vs. 9 months, p = 0.0122, HR = 0.56, 95% CI = 0.36–0.88, Figure 2F). Here, CDK4 is linked to adrenal cortex carcinoma.