Considering the fact that (1) the CDK4 gene was overexpressed in 62% of ACC samples, (2) CDK4/6 inhibitors such as palbociclib are already approved for breast cancers and under clinical trials for other solid tumors, (3) CDK4 expression correlated with the presence of CN gains at DNA level (2), and (4) palbociclib has been previously tested in ACC cell lines with promising results (28, 31), we decided to focus on CDK4 as our best potential drug target for ACC. The gene discussed is CDK4; the disease is adrenal cortex carcinoma.