In particular, it seems to be feasible in the near future to pre-select ACC patients that might potentially benefit from a treatment with CDK4/6 inhibitors, consistent with the presence of CDK4 CN gains (at DNA level, 43% of cases) and/or CDK4 overexpression (at mRNA or protein level) in the tumor, while linsitinib might be an interesting combination partner in patients with both IGF2 and IGF1R overexpression. The gene discussed is IGF2; the disease is adrenal cortex carcinoma.