CDK4 and neoplasm: In particular, it seems to be feasible in the near future to pre-select ACC patients that might potentially benefit from a treatment with CDK4/6 inhibitors, consistent with the presence of CDK4 CN gains (at DNA level, 43% of cases) and/or CDK4 overexpression (at mRNA or protein level) in the tumor, while linsitinib might be an interesting combination partner in patients with both IGF2 and IGF1R overexpression.