• Lower concentrations of BNDF• Insulin-resistance• Increase in serum prolactin (only female in short term treatment)• Decrease in serum prolactin (long term treatment)• Hyperinsulinemia• Diabetic ketoacidosis• Increase in leptin• Decrease in ghrelin• Increase in postprandial ghrelin (rats)• Decrease in cortisol. The gene discussed is LEP; the disease is hyperinsulinism.