TNF and Decreased total leukocyte count: • Neutropenia• Leukopenia• Agranulocytosis,• Thrombocytopenia• In vitro: low levels of IL-2• In vitro: high levels of TNF-α and IL-17• In vitro: high levels of IL-4 and IL-10• In vitro: low levels of IFN-γ• High plasma levels of BDNF