INS and hyperprolactinemia: • Hyperprolactinemia (human and pigtail macaques).• Decrease in testosterone levels in women and estradiol levels in both genders.• Increase in leptin and insulin levels.• Increase in TSH levels.• Decrease in adiponectin levels.• Increase in insulin levels in FVB/N line (mice).• Decrease in α-MSH, AgRP, and CART (rats).• Increase in glucagon, leptin, and ghrelin levels (rats).• Ovarian mitochondrial dysfunction (rats).