In the present work, we used spontaneous ZDF rats as a T2DM model and examined the hypothesis that ZBPYR could reverse the impairment of chronic psychological stress leading to DACD, mainly by reducing Aβ deposition through the IRS-1/AKT/mTOR signaling pathways in the medial prefrontal cortex (mPFC). The gene discussed is MTOR; the disease is type 2 diabetes mellitus.