We have revealed that “transport of small molecules”, “disease”, “metabolism” and “metabolism of proteins” were the most relevant signaling sections, among which “transport of inorganic cations/anions and amino acids/oligopeptides”, “SLC-mediated transmembrane transport”, and “metabolism of amino acids and derivatives” should be further studied to elucidate their potential pathogenic mechanism in the development of depression and associated suicidal behavior. This evidence concerns the gene CCL21 and depressive disorder.