CCL21 and major depressive disorder: We have revealed that “transport of small molecules”, “disease”, “metabolism” and “metabolism of proteins” were the most relevant signaling sections, among which “transport of inorganic cations/anions and amino acids/oligopeptides”, “SLC-mediated transmembrane transport”, and “metabolism of amino acids and derivatives” should be further studied to elucidate their potential pathogenic mechanism in the development of depression and associated suicidal behavior.