CAMK2G and ischemia: At the same time, there could be a contribution of emergent, X-ROS-independent mechano-transduction pathways (e.g., via direct effects relating to the baseline increase in [Ca2+]i or ROS with ischemia on mechano-sensitive ion channel activity, CaMKII activation, RyR sensitivity to Ca2+, or mitochondrial-derived Ca2+ and ROS production).