FMO5 and endothelial dysfunction: It is well established that endothelial dysfunction induced by AngII was also associated with increased production of ROS from both NADPH oxidase (Griendling et al., 1994; Li and Shah, 2003; Sanchez et al., 2007) and mitochondria (Doughan et al., 2008; Dikalov et al., 2014) in vascular cells.