Treatment with the rodent-specific PXR ligand PCN protects against dextran sulfate sodium (DSS)-induced mouse acute colitis via suppressing NF-κB signaling pathway, but such treatment does not decrease the severity of DSS-induced colitis in PXR knockout mice, indicating a role for PXR agonist in protection against IBD (Shah et al., 2007). This evidence concerns the gene NR1I2 and inflammatory bowel disease.