Blocking of NF-κB activation with SCAs by inhibiting the phosphorylation of p65 and IκB-α, thereby protecting IκB-α from degradation, has been shown in LPS-activated RAW264.7 macrophages (Heo et al., 2014) and in IL-1β-activated MG-63 osteosarcoma fibroblasts (Yoon et al., 2012b) for SCA D (60 μM) and G (20 μM), respectively. Here, NFKBIA is linked to osteosarcoma.