Moreover, the expression of transcription factor EB (TFEB), the master regulator of lysosomal biogenesis and autophagy, is significantly decreased in SNpc dopaminergic neurons of PD patients and its staining co-localizes with Lewy bodies, a neuropathological hallmark of PD (Decressac et al., 2013). The gene discussed is TFEB; the disease is Parkinson disease.