PRKN and Parkinson disease: Interestingly, genetic mutations associated with increased risks for developing PD, like α-synuclein, LRRK2, beta-glucosidase 1 (GBA1; lysosomal glucocerebrosidase), Parkin, PTEN-induced kinase 1 (PINK1), DJ-1, Fbxo7, and VPS35, encode for components of the autophagy–lysosome pathway, thus confirming a tight link between the autophagy dysfunction and PD (Gan-Or et al., 2015; Verstraeten et al., 2015; Przedborski, 2017).