Based on these findings, a multicenter phase II, randomized, double-blind, placebo-controlled study supported by Sanofi-Genzyme, is investigating the safety, pharmacokinetics, and pharmacodynamics of Venglustat (GZ/SAR402671), an oral inhibitor of glucosylceramide synthase in GBA1 carriers with early-stage PD (MOVES-PD study: NCT02906020). Here, GBA1 is linked to Parkinson disease.