Though alpha-synuclein conformation change and accumulation were traditionally thought to occur in the neuron itself, recent evidence supports that alpha-synuclein is excreted into extracellular spaces (Emmanouilidou et al., 2011), making the neuropathological underpinnings of CSF-ISF flow in the pathogenesis of neurodegenerative disease processes is of high interest. Here, SNCA is linked to neurodegenerative disease.