AQP4 and neuromyelitis optica: The role of AQP4 in neuroinflammatory conditions potentially linked to impaired glymphatic clearance has been investigated in EAE, as well as neuromyelitis optica (NMO), an inflammatory disease characterized by autoantibodies against AQP4 resulting primarily in complement-dependent astrocyte injury and secondarily in neuroinflammation, demyelination, and neuronal loss.