As a proof of a novel concept for the BGA, we use three previously validated immunological CSF markers of tuberculous meningitis (TBM) – vascular endothelial growth factor (VEGF), interferon-gamma (IFN-γ), and myeloperoxidase (MPO) – to model/predict the metabolic changes, and are the basis for postulating a metabolic cascade, expected within the brain of a TBM patient. Here, IFNG is linked to meningeal tuberculosis.