NFE2L2 and neurodegenerative disease: Of note, many studies found that Nrf2 is expressed in the central nervous system (CNS), neurons, astrocytes, leukocytes, and microglia (Tanaka et al., 2011; Dang et al., 2012; Sandberg et al., 2014), and numerous evidence suggests that Nrf2 plays an important role in the development and treatment of neurodegenerative diseases (Wang et al., 2017; Deng et al., 2019; Jang et al., 2019; Pachón-Angona et al., 2019; Wei et al., 2019).