NFE2L2 and neurodegenerative disease: Nrf2 has already acted as a well-known target for neurodegenerative disease treatment (de Oliveira et al., 2018; Muhammad et al., 2019; Wang et al., 2019a) and plays a key role in neuronal resistance to oxidative stress and glutamate-induced excitotoxicity and promotes neuronal degeneration and neuronal survival in acute nerve injury.