NCOA4 and neurodegenerative disease: Through literature review, it is speculated that in animal models of neurodegenerative diseases, depletion of long-term nuclear receptor-assisted activator (NCOA4) in the brain can worsen the neurodegenerative disease phenotype due to the further inappropriate accumulation of free iron and resulted in oxidative stress (Quiles Del Rey and Mancias, 2019), and then induced ferroptosis in nerve cells.