When investigated, ferroptosis in CD8 + T cells that is activated by cancer immunotherapy, the interferon-gamma (IFNγ), downregulates the expression of SLC3A2 and SLC7A11, impairs the uptake of cystine by tumor cells, and as a consequence, promotes tumor cell lipid peroxidation and ferroptosis (Wang et al., 2019d). The gene discussed is CD8A; the disease is neoplasm.