Proteins such as lipoproteins, antibodies and IAPP (also called amylin) are not able to perform their homeostatic, immunological, or hormonal functions in their pathological amyloid forms in Apo-AI amyloidosis, light-chain amyloidosis and diabetes, respectively (Hieronymus and Griffin, 2015; Muchtar et al., 2016; Lu et al., 2017). The gene discussed is IAPP; the disease is AL amyloidosis.