Recognizing this problem, Volpatti et al. plan to re-do their screens on mice or cells carrying missense mutations analogous to those found in malignant hyperthermia (Lopez et al., 2018), or the more complex mutations found in patients with RyR1-related myopathies (see, for example, Brennan et al., 2019). This evidence concerns the gene RYR1 and Malignant hyperthermia.