Interestingly, the lncRNA GATA6‐AS1 was also downregulated in IVL GATA6‐AS1 is involved in vascular disease and may be associated with the upregulation of GATA2. Using RT‐qPCR, we validated these results in samples from IVL patients and showed that the expression of SH2D2A and GATA2 were upregulated, while CXCL8, LIF, and VASH2 were downregulated in the IVL tumor samples compared to the nontumor samples (Figure 7). Here, SH2D2A is linked to neoplasm.