These include generalized arterial calcification of infancy-1 and infancy-2 (GACI1 and GACI2), caused by bi-allelic mutations in ENPP1 or ABCC6, respectively [9], or the PXE-like syndrome with multiple coagulation factor deficiency, caused by bi-allelic GGCX mutations [18]. The gene discussed is ABCC6; the disease is body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency.