SIRT2 and nasopharyngeal carcinoma: Similarly, SIRT2-mediated FOXO3 deacetylation has also been implicated in lapatinib response and sensitivity, and that SIRT2 can specifically antagonise the cytotoxicity of lapatinib through mediating FOXO3 deacetylation in both sensitive and resistant nasopharyngeal carcinoma (NPC) cells.