In a similar manner to the FOXO1 chromosomal translocation in alveolar rhabdomyosarcoma, FOXO3 (also known as FKHRL1) and FOXO4 (also known as AFX) are translocated to the MLL gene in mixed lineage leukaemia (MLL), an aggressive paediatric blood cancer [11]. Here, KMT2A is linked to hematopoietic and lymphoid system neoplasm.