Indeed, recent research has shown that PERK (PKR-like endoplasmic reticulum kinase, also called eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2A3K)) is regulated by FOXO3 and thus exposed a transformed cell and chemotherapeutic drug–resistant cancer cell vulnerability in PERK [155]. The gene discussed is EIF2AK3; the disease is cancer.