FOXO1 and cancer: Although there is no evidence of a direct link between MKP and FOXO activities in human cancer, a study has demonstrated that insulin-induced MKP3 (also known as dual-specificity phosphatase 6; DUSP7) interacts and dephosphorylates FOXO1 on Ser256 in a mouse model to promote its nuclear import for gluconeogenic gene transcription [138].