HK1 and metastatic colorectal cancer: In a previous study in metastatic colorectal cancer [6], we found mRNA tumor overexpression of GLUT-1 and the glycolytic genes hexokinase 1 (HK-1) and 2 (HK-2), pyruvate kinase isoform 2 (PKM-2) and lactate dehydrogenase isoform A (LDH-A).