Luciferase reporter assays further revealed that HCC cells co-transfected with LINC01278-wt and TCF-4 showed significantly increased luciferase activities relative to the control group, whereas HCC cells co-transfected with TCF-4 and LINC01278 with the binding sequence mutated showed no significant change in luciferase activities versus the control group (Fig. 5c). This evidence concerns the gene TCF4 and hepatocellular carcinoma.