Down-regulated genes contain markers enriched in mature hepatocytes (Tat, Cyp7a1, Apoa5, Pck1, Cyp3a11, Mup3 or Acsl1) and tumor suppressors (Lect2, Wfdc17 or Efemp1) (Fig. 6d). The gene discussed is LECT2; the disease is neoplasm.