Concordantly, interfering with proteolytic activities of the non-lysosomal thiol protease calpain-2 (CAPN2), present exclusively in MIH saliva, could potentially limit the ongoing tissue/bone degradation as calpain-2 inhibitor(s) reportedly reduce colitis and colitis-associated cancer through limiting macrophage activation and inhibiting growth of cancer cells54. The gene discussed is CAPN2; the disease is cancer.