A recent study has demonstrated that alternations in the stoichiometry of MCU complexes causes a change in the Ca2+ influx into the mitochondria.28 Furthermore, Julia et al. reported that the MICU1 functions as a gatekeeper to inhibit mitochondrial Ca2+ overload.29 Our data indicated that the mRNA expression of MICU1, but not other members of the MCU complex is downregulated in CRC tissues, suggesting that MICU1 may function together with MCU to regulate the level of mitochondrial Ca2+ in CRC cells. The gene discussed is MICU1; the disease is colorectal carcinoma.