ETHE1 and colorectal cancer: For example, Witherspoon et al.14 indicated that the constitutive expression of ETHE1 increases aerobic glycolysis (“Warburg effect”), oxidative phosphorylation, and mitochondrial biogenesis in colorectal cancer (CRC) cell lines.35 Yang and colleagues36 suggested that mitochondrial biogenesis and maintenance may play an important part in tumor cell survival during CRC progression.