NFKB1 and colorectal carcinoma: Furthermore, treatment with H2O2 increased cell viability and the percentage of EDU-positive cells and clearly reversed the effect of MCU knockdown in CRC cells, whereas both the ROS scavenging by Mito-TEMPO and NF-κB-specific inhibitor Bay11–7082 decreased cell viability and the percentage of EDU-positive cells, clearly reversed the effect of MCU overexpression in CRC cells (Fig. 7f, g and Supplementary Fig. S5).