One recent study also indicated that high-mitochondrial Ca2+ mediated by MCU increases prostate cancer cell proliferation by inhibiting mitochondrial permeability transition pore (mPTP).13 Although the biological role of MCU in the progression of several cancer types has been extensively studied, it remains unclear whether MCU is involved in CRC cell growth via the regulation of mitochondrial Ca2+ uptake. This evidence concerns the gene MCU and colorectal carcinoma.