MDM2 and hepatocellular carcinoma: Growing evidence has demonstrated that MCU possesses pivotal roles in different types of cancers.8–10 For example, it has been reported that the expression of MCU elevated in basal-like and estrogen receptor-negative breast cancers, and the depletion of MCU promotes caspase-independent apoptosis in breast cancer cells.9 Similarly, our previous study demonstrated that MCU is upregulated in HCC cells and promotes HCC cell survival via the ROS/AKT/MDM2 pathway.11 Furthermore, Tosatto et al.12 have reported that MCU is instrumental for the growth of triple-negative breast cancer.