A number of studies have demonstrated that deregulation of MCU is associated with different types of cancer.7 For instance, it has been reported that the expression of MCU is elevated in various types of cancer, including breast cancer25 and hepatocellular carcinoma.11 Consistently, our data indicated that the mRNA and protein expression levels of MCU were frequently upregulated in CRC cells and tissues, which then contributed to poorer OS of patients with CRC. Here, MCU is linked to cancer.