In UK Biobank, gene-wide DRICH1 variants were associated with several intestinal death causes (diverticular disease with perforation and abscess, P = 2.9 × 10−10; gastro-intestinal hemorrhage, P = 1.6 × 10-9; acute vascular disorders of the intestine, P = 3.5 × 10−6) and lymphocytic cancer-related deaths (unspecified T-cell lymphoma, P = 7.9 × 10−19; unspecified non-hodgkins lymphoma, P = 1.9 × 10−6; chronic lymphocytic leukemia, P = 4.4 × 10−6). Here, DRICH1 is linked to diverticular disease.