Area under the receiver operating characteristic (ROC) curve (AUC) for the diagnosis of HF in the validation cohort of patients without and with HF (study cohort 1, n = 100) demonstrated a significantly higher diagnostic specificity and sensitivity of serum Tetranectin in univariate analysis (AUC = 96.6% [93.2–99.9%]) compared to the gold-standard marker BNP (AUC = 83.7% [74.8–92.6%]), p = 0.011, Fig. 2. The gene discussed is NPPB; the disease is hydrops fetalis.