CHDH and osteosarcoma: C-AYA patients with CNS (32 variants), neuroblastoma (21), rhabdomyosarcoma (15), and Wilms (15) tumors had the highest number of CHD-related gene variants, and patients with retinoblastoma (2) and osteosarcoma (2) tumors had the least number of those variants (Supplementary Fig. 7; Supplementary Data 16).