Future prospective research with larger sample sizes would benefit from extending beyond the analysis of routine, standard of care clinic data and to confirm that weight loss is caused by cachexia and not other factors, that the loss in body weight is related to the decline in muscularity and function, and to concomitantly identify other systemic inflammatory biomarkers that associate with cachexia, such as C-reactive protein, various interleukins or cytokines, angiotensin II, and neutrophil-derived proteases. This evidence concerns the gene CRP and Cachexia.