MAPT and Cognitive impairment: Thus the 6 m time point of the J20-hAPP mouse could be considered as an equivalent of EMCI in humans; characterised by some memory deficits, structural and functional alterations within the brain including Aβ deposits, neuronal & synaptic loss in hippocampus as well as neuroinflammation, though with the notable exception of any tau pathology as well as displaying cognitive impairments before significant Aβ deposition.