BRD2 and HIV infectious disease: Regarding HIV testing in the context of PrEP, the WHO PrEP implementation tool notes that using assays capable of identifying acute infection, such as NAT, where feasible may offer additional benefits as those seeking PrEP could be at heightened risk of having acute HIV infection.7 However, to date, WHO has not issued recommendations on the use of NAT in the context of PrEP.