The most widely used model of pancreatitis involves treatment with the cholecystokinin agonist caerulein, which induces local oxidative stress, inflammation, edema, and loss of the acinar parenchyma that is transiently replaced by a duct-like epithelium, features reminiscent of human pancreatitis (Su et al, 2006; Guerra et al, 2011). This evidence concerns the gene CCK and pancreatitis.