CTLA4 and neoplasm: If both targets are expressed on Treg cells (such as CTLA-4xGITR), or one on a Treg cell (CTLA-4) and the other on a MDSC cell (such as CSF1R), or both ICP targets on tumor cells (e.g., PD-L1xCD47), then IgG1 should be selected so that the immunosuppressive cells (Treg, MDSC) or tumor cells over-expressing ICPs (e.g., PD-L1xCD47) can be eliminated via IgG1-mediated ADCC/ADCP.