Taking our CD47xCD20 bispecific molecule (IMM0306) as an example (unpublished data), both CD47 and CD20 are highly expressed in tumor cells (in this case, tumor cell is a B cell), as such, IgG1 format was selected to (1) block the “don't eat me” signal resulting from CD47-SIRPα interaction; and (2) activate innate immune cells via Fc-FcγR interaction (Fig. 2) (unpublished data). This evidence concerns the gene SIRPA and neoplasm.