In conclusion, retinal vascular leakage is the fundamental pathological change in Coats disease, accompanied by the increase of various AH cytokines, including VEGF, IL-6, IL-8, MCP-1, MIP-1α, IP-10, VACM-1 and ICAM-1, which is involved in angiogenesis, increased vascular permeability and inflammatory response and may contribute to the pathogenesis and progression of the disease. This evidence concerns the gene CXCL10 and Coats disease.