CD8A and neoplasm: After the adjustment of clinical factors (age, gender, ethnicity, tumor stages and tumor purity), we found that the lower infiltrates of B cell, CD8+ T cell, Neutrophil, and Dendritic cell was significantly associated with a poor survival rate of SKCM and SKCM-metastasis patients (Fig. 5a-b) which is consistent with the previous study [6].