It was showed that SRGN was significantly highly expressed in KIRC (kidney renal clear cell carcinoma) and significantly lower expressed in BLCA (bladder urothelial carcinoma), BRCA (Breast invasive carcinoma), COAD (colon adenocarcinoma), KICH (kidney chromophobe), LIHC (liver hepatocellular carcinoma), LUAD (lung adenocarcinoma), LUSC (Lung squamous cell carcinoma), PRAD (prostate adenocarcinoma), READ (Rectum adenocarcinoma) and UCEC (Uterine Corpus Endometrial Carcinoma) (P < 0.001, Fig. 1b). The gene discussed is SRGN; the disease is rectum adenocarcinoma.